An external file that holds a picture, illustration, etc. To determine the effects of topical insulin administration on burn wound healing in rats with or without acute diabetes. The present study aims at evaluating the selective inhibition of cox1 andor cox2 by. Active constituents of asparagus racemosus steroidal saponins are main active constituents of a. Request pdf antisecretory and antiulcer activity of asparagus racemosus willd. Cyperus rotundus, onosma bracteatum, barleria prionitis, citrus maxima, tinospora cardifolia and asparagus racemosus etc are significantly utilized by the local peoples of uttarakhand.
Antioxidant determination by the use of stable free radical. Mulethi is useful in cough, sore throat, bronchitis, sexual weakness, skin problems, jaundice, hoarseness, vata dosha, ulcers etc. Preclinical screening of antiulcer activity of asparagus racemosus. Polyherbal antiulcer formulation is developed and evaluated for various physical, chemical and biological aspects. Cuscuta, commonly known as dodder, is a genus of family convolvolaceace. Gastric ulceration studies have been further carried out to study the antiulcer effect of the ethanolic extract and its. The effect of saptachchhada kwatha and pinda taila on vipadika tenia pedis treatment of duodenal ulcer with asparagus racemosus linn. The demand for asparagus racemosus in 20012002 was 10,924. Toxicological survey of african medicinal plants various guidelines have been established to identify potential risk for carcinogenicity and heritable mutations 56,57. Pharmacological evaluation for antidepressantlike activity. Plants are known to play critical roles in the discovery and developments of new pharmaceuticals. The aqueous extract of glycyrrhiza glabra, emblica officinalis, zingiber officinale and asparagus racemosus were prepared using micorwave assisted extraction techniques and extracts were standardized before their use to prepare formulation. Cox2specific inhibitors offer improved advantages over traditional nsaids.
For example, the pdf reader software is required to view the pdf format document. Summary the present study was undertaken to investigate the effect of asparagus racemosus. The hematinic activity was conducted in swiss albino rats by single intra peritoneal injection of phenyl hydrazine at a dose of 20mgkg b. Its underground stems and roots are used for medicinal purpose. A series of experiments to evaluate the mechanisms of adaptogenic activity of asparagus racemosus using various stress an d immunostimulatory models are reported in the literature few of which are as sited below. Ssr tamil university volume ii doctor of philosophy. Gastroduodenal ulcer protective activity of asparagus racemosus. The major active constituents of asparagus racemosus are steroidal saponins shatavarins iiv that are present in the roots. The newly prepared compounds were screened for their in vitro antioxidant activities using free radical scavenging 2,2diphenyl1picrylhydrazyl dpph and ferric reducing antioxidant power frap assays. Those possessing significant antiulcer activity have been processed further for the evaluation of the activity. Against indomethacin plus pyloric ligationinduced gastric ulcer in rats to. Shatavari was found to relive most of the symptoms in majority of the patients. The major bioactives chemical constituents of asparagus species are shown in figure 2. Asparagus racemosus is an herbaceous perennial plant.
Exploring indian medicinal plants for antiulcer activity. Synthesis of sarsasapogenin in the callus culture of a. Methanol extracts from the leaves of intsia bijuga, cynometra ramiflora. Asparagus racemosus, asparagus adescendens, chlorophytum borivilianum, chlorophytum laxum and chlorophytum arundinaceum are regarded as source of safed musli, leading to confusion about its identity and usage, whereas asparagus species is largely employed for the treatment of female. The study found that 3,200 milligrams of asparagus racemosus had diuretic activity without causing acute side effects. Cistus laurifolius rockrose flowers and flower buds of cistus laurifolius l. The information provided by this web site is available in various formats, such as portable document format pdf, word, and also in html format. The asparagus genus asparagaceae has over 300 species which are widely distributed in temperate and tropical regions including india, china, korea and japan. Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug activity specificity determination, and basic metabolic research requires new data preprocessing approaches to correlate specific metabolites to their biological origin. Asparagus racemosus, steroidal saponins, application, herbal.
There are many reasons for undertaking detailed research on the activity of. Phenolic contents of ethanolic extracts of herbs were high compared to their aqueous extracts. To view the information properly, your browser needs to have the required plugins or software. The major challenge in genotoxicity testing resides in developing methods that can reliably and. June 2014 pdf vermont center for integrative herbalism. Andradeevaluation of antiulcer activity of the main phenolic acids. The root extract of asparagus racemosus has also been traditionally used in ayurveda to increase milk secretion during lactation. Gastric ulceration studies have been further carried out to study the antiulcer effect of the ethanolic extract and its various fractions at dose of 900 mgkg body weight. Exploring indian medicinal plants for antiulcer activity bioline. The file contains 92 pages and is free to view, download or print. Antioxidant activity and antiapoptotic effect of asparagus racemosus root extracts in human lung epithelial h460 cells. Shatavarin iv is a glycoside of sarsasapogenin having two molecules of rhamnose and one molecule of glucose. Preliminary report journal of scientific research in plants and medicine.
Metabolomic profiling of five agave leaf taxa via uhplcpda. Patel department of pharmacology, institute of pharmacy, nirma university, ahmedabad, 1maliba pharmacy college, bardoli, surat, gujarat, india. The effects of restraint on uptake of radioactive sulfate in the salivary and gastric secretions of rats with pyloric ligation. Bhatnagar m, sisodiya ss, bhatnagar r 2005 antiulcer and antioxidant activity of asparagus racemosus willd and withania somnifera dunal in rats. Approximately 170 species of cuscuta are extensively distributed in temperate and subtropical areas of the world. The aim of the present study is to investigate the gastroprotective activity of c. The percentage atpase inhibitory activity of the extract and omeprazole was also expressed in terms of 50% inhibitory concentration ic 50 value. Ayurveda research digest complete vol1 pdf free download. In recent times, the use of herbal products has increased tremendously in the western world as well as in developed countries. There is urgent need to document the medicinal and aromatic plants associated traditional knowledge which is vulnerable to minimize. Bhatnagar m, sisodia ss, 2006, antisecretory and antiulcer activity of asparagus racemosus wild, against indomethacin plus phyloric ligationinduced ga stric ulcer in rats. Indian medicinal plants, peptic ulcer, ocimum sanctum. Plant profile, phytochemistry and pharmacology of asparagus racemosus. Licorice or mulethi is a medicinal herb which is used in various ayurvedic medicines.
Cistaceae are used in the treatment of peptic ulcers in south anatolia honda et al. All tests were performed in triplicate, expressed as mean sem and presented in tables and bar graphs where appropriate. Immunomodulatory effects of betulinic acid from the bark of white birch on mice jine yi, 1 bozena obminskamrukowicz, 2 liyun yuan, 1 and hui yuan 1 1 college of animal medicine, hunan agricultural university, changsha, 410128, p. The aqueous extract of roots increased the weight of mammary glands in post partum and estrogenprimed rats and the uterine weight in the estrogenprimed group 11. Flavanones from sorghum bicolor selectively inhibit cox2. The compound carbenoxolone synthesized from glycyrrhizin plays key role in healing mouth and gastric ulcers along with reducing gastric secretions and promoting.
A series of new 2ethylthiobenzohydrazone derivatives 16 were prepared and characterised by ir, 1h nmr, and c nmr spectroscopy and mass spectrometry. Antisecretory and antiulcer activity efficacy of a. The present study evaluates the effects of extract of musa sapientum fruit mse on ulcer index, blood glucose level and gastric mucosal cytokines, tnf. Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug activityspecificity determination, and basic metabolic research requires new data preprocessing approaches to correlate specific metabolites to their biological origin. Methods we freely listed the medicinal plants used in the bsm literature, current formulations, and the medicinal plants inventory documents. Compendium of medicinal and aromatic plants volume 2 free ebook download as pdf file. Metabolomic profiling of five agave leaf taxa via uhplc.
Abstracts of papers for poster sessions indian j pharmacol. Ethnoveterinary plant remedies used by nu people in nw yunnan of china. Acute toxicity test was carried out on 36 rats 18 males and 18 females with low. The possible antioxidant effects asparagus racemosus against membrane damage induced by the free radicals generated during gammaradiation were examined in rat liver mitochondria.
Agave plants proved to possess significant anticancer, immunostimulant, antiinflammatory, antimicrobial and antioxidant properties, owing to the prevailing. Shatavarins containing shatavarin iv with anticancer activity from. Ssr tamil university volume ii doctor of philosophy tamil. This research aims to evaluate the antiulcer properties of medicinal plants. According to a 2010 study on rats, asparagus racemosus is used as a diuretic in ayurveda.
Agaves family agavaceae are perennial plants, native to mexico and southwestern united states. Drug treatment was carried out for 14 days at 2 dose level 200mgkg p. The major challenge in genotoxicity testing resides in developing methods that can reliably and sensibly detect cellular response to genotoxic insult. Antisecretory and antiulcer activity of asparagus racemosus willd. Asparagus racemosus is an ayurvedic rasayana, which finds mention in. Species of this genus are widely used as essential constituents in functional foods and traditional medicinal systems. They have been used as a traditional medicine for the treatment of stomach ulcers, gastritis, wounds and psoriasis. Evaluation of acute toxicity and gastroprotective activity. The analgesic activity of the ethanolic extract and its fractions has been carried out by tailflick method and writhing test at a dosage of 300 mgkg po.
Antiulcer activity treatment with ethanolic extract of c. Acute toxicity test was carried out on 36 rats 18 males and 18 females with low dose of. The possible antioxidant effects asparagus racemosus against membrane damage induced by the free radicals generated during gammaradiation were examined in. Pharmacological and therapeutic application of asparagus. Antioxidant properties and gastroprotective effects of 2. Effect of added herb extracts on oxidative stability of ghee. Volume 2 of this unido publication is on asian botanicals. The antioxidant activities of vidarikand pueraria tuberosa, shatavari asparagus racemosus and ashwagandha withania somnifera extracts aqueous and ethanolic were evaluated and compared with bha using. Antiulcer and antioxidant activity of asparagus racemosus willd and. Publish subscribe model in webmethods pdf download. Various parts of many members of cuscuta have been found efficacious against a variety of.
Reactive oxygen species ros and free radicals such as superoxide anion radical, hydroxyl radicals, and lipid peroxides are the injurious species known to cause many degenerative diseases. To the best of our knowledge, nothing has been reported so far on the selective inhibition of the cyclooxygenase by flavanones. Herbal aphrodisiacs or sexual stimulant plants viz. Pharmacological evaluation for antidepressantlike activity of asparagus racemosus willd. Here we introduce an lcmsbased data analysis approach, xcms, which incorporates novel nonlinear retention time alignment, matched filtration. In asparagus racemosus, there is an almost 100% mark up in price from the collector level to the user tewari, 2000. It has antioxidant, antimicrobial, antiinflammatory and hepatoprotective properties. Results were compared with the standard antiulcer drug omeprazole. There are evidences for the aid of ros in the etiology and pathophysiology of human diseases, such as neurodegenerative disorders, viral infections, autoimmune gastrointestinal inflammation. Its medicinal properties are reported in traditional systems of medicine such as ayurveda, siddha and unani.
Asparagus racemosus, asparagus adescendens, chlorophytum borivilianum, chlorophytum laxum and. Evaluation of acute toxicity and gastroprotective activity of. A potential of some medicinal plants as an antiulcer agents ncbi. Effect of added herb extracts on oxidative stability of. Antiulcer activity of asparagus racemosus pdf free. The anticancer activity of shatavarins containing shatavarin iv isolated from the roots of. Toxicological survey of african medicinal plants mafiadoc. The present investigation revealed that ocimum sanctum exhibited significant antiulcer activity by enhancing antioxidant potential of gastric mucosa thereby reducing mucosal damage. Evaluation of burn wound healing activity of topical regular insulin in normal and diabetic rats bairy kl, abhinav r. Medicinal plants are the natures gift to human being to make disease free healthy life. No category june 2014 pdf vermont center for integrative herbalism. China 2 department of biochemistry, pharmacology and toxicology, faculty of veterinary medicine, wroclaw university of environment and life science, norwida 31. Siotone st is a herbal formulation comprising of withania somnifera, ocimum sanctum, asparagus racemosus, tribulus terristris and shilajit, all of which are classified in ayurveda as rasayanas which are reputed to promote physical and mental health, improve defence mechanisms of the body and enhance longevity. More study is needed on humans before asparagus racemosus can be safely recommended as a diuretic.
Ssr tamil university volume ii free ebook download as pdf file. Antiulcer activity the potent antioxidant and antiinflamatory properties of licorice makes it the best natural medicinal aid to treat ulcers of stomach, intestine and mouth. Asparagus rhamnose and 1 molecule of glucose figure 1. Compendium of medicinal and aromatic plants volume 2. Asparagus racemosusethnopharmacological evaluation and. Sarsasapogenin and shatavarin iiv are present in roots, leaves, and fruits of asparagus species.
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